Thursday, May 1, 2008

Quảng cáo - phát hiện gien loãng xương (mới)

Trong blog này tôi ít khi nào tự quảng cáo công việc, nhưng hôm nay phải phá lệ vì một tin vui. Nhóm nghiên cứu của tôi qua cộng tác với một công ti bên Iceland vừa phát hiện một số SNP có liên quan đến loãng xương và gãy xương. Đây là một nghiên cứu rất đắt tiền, chúng tôi phải phân tích trên 300 ngàn SNP cho mỗi bệnh nhân, và cuối cùng chỉ thấy có 12 SNP quan trọng.

Tôi nói qua “cộng tác”, bởi vì các cơ quan y tế Úc chưa bao giờ tài trợ dự án này cho tôi, nên đành phải nhờ công ti Iceland phân tích gien. Công ti này rất thành công trong công nghệ sinh học, không có công nghệ của họ, tôi chẳng làm gì được với mấy gien này.

Bây giờ thì nhóm của tôi còn phân tích 12 SNP này để biết chính xác chúng liên hệ như thế nào với loãng xương và sẽ tìm cách sử dụng thông tin từ gien để tiên lượng và chẩn đoán gãy xương. Một chương mới trong loãng xương đang được mở ra. Rất vui mình là người tham gia vào việc mở “chương sách” này. Hôm nay là một ngày vui của tôi. :-)

Kèm theo đây là vài bản tin báo chí để các bạn biết.

NVT

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http://www.medicalnewstoday.com/articles/105952.php

Seeking An Osteoporosis Fingerprint Through Genotyping

Main Category: Bones / Orthopaedics
Also Included In: Genetics
Article Date: 01 May 2008 - 3:00 PDT

For the first time ever, an extensive genome-wide search has been undertaken to find the genes linked to osteoporosis and fracture. Five regions of interest have been identified that appear to warrant further scientific investigation.

From the age of 60, 40% women and 25% men will sustain a fracture due to osteoporosis, with the risk being higher in people with a family history of fracture. There are 30,000 genes in the human genome, but until now few have been unequivocally linked to osteoporosis and fragility fractures.

The Garvan Institute for Medical Research collaborated with the Icelandic genetics company, deCode, in a project that looked at 1500 women from Garvan's Dubbo Osteoporosis Epidemiology Study as well as more than 12,000 women from Iceland and Denmark.

The results of this multi-nation study are reported in a paper appearing online today in the New England Journal of Medicine.

"Genome-wide genotyping, a very demanding and labour-intensive procedure, measures genetic variations called 'Snips' (SNPs or single nucleotide polymorphisms), within each of our 30,000 genes," said Garvan's Associate Professor Tuan Nguyen, who has been involved with the Dubbo project over a period of nearly 20 years. "The collaborative study examined more than 300,000 such markers and found 12 that were linked to bone mineral density and 6 linked to fragility fractures. Some of these Snips are close to genes that are already known to be associated with osteoporosis,"

Professor John Eisman, Head of Garvan's Bone Program, is very pleased with these findings. "This international study and the access to the information it brings is a positive example of the value of world-wide scientific collaborations in the area of human genetics. The study identified a number of regions in the human genome that are already known to be important in bone biology, while others are yet to be investigated," he said.

"The next step will be identifying what those genes are and how they might contribute to our understanding of osteoporosis and its prevention. This is an important example of Australian science participating in international science at the highest level."

The discovery of genes linked to osteoporosis will allow researchers to better develop prognostic models, and help clinicians identify individuals with high risk of fracture for intervention.

http://www.sciencedaily.com/releases/2008/04/080430091115.htm

Genotyping Takes Us Closer To An Osteoporosis Fingerprint

ScienceDaily (May 1, 2008) — For the first time ever, an extensive genome-wide search has been undertaken to find the genes linked to osteoporosis and fracture. Five regions of interest have been identified that appear to warrant further scientific investigation.

From the age of 60, 40% women and 25% men will sustain a fracture due to osteoporosis, with the risk being higher in people with a family history of fracture. There are 30,000 genes in the human genome, but until now few have been unequivocally linked to osteoporosis and fragility fractures.

The Garvan Institute for Medical Research collaborated with the Icelandic genetics company, deCode, in a project that looked at 1500 women from Garvan's Dubbo Osteoporosis Epidemiology Study as well as more than 12,000 women from Iceland and Denmark.

"Genome-wide genotyping, a very demanding and labour-intensive procedure, measures genetic variations called 'Snips' (SNPs or single nucleotide polymorphisms), within each of our 30,000 genes," said Garvan's Associate Professor Tuan Nguyen, who has been involved with the Dubbo project over a period of nearly 20 years. "The collaborative study examined more than 300,000 such markers and found 12 that were linked to bone mineral density and 6 linked to fragility fractures. Some of these Snips are close to genes that are already known to be associated with osteoporosis."

Professor John Eisman, Head of Garvan's Bone Program, is very pleased with these findings. "This international study and the access to the information it brings is a positive example of the value of world-wide scientific collaborations in the area of human genetics. The study identified a number of regions in the human genome that are already known to be important in bone biology, while others are yet to be investigated," he said.

"The next step will be identifying what those genes are and how they might contribute to our understanding of osteoporosis and its prevention. This is an important example of Australian science participating in international science at the highest level."

The discovery of genes linked to osteoporosis will allow researchers to better develop prognostic models, and help clinicians identify individuals with high risk of fracture for intervention.

The results of this multi-nation study are reported in a paper appearing online April 30 in the New England Journal of Medicine.

http://www.keralanext.com/news/?id=1222218

Genome-wide search uncovers genes linked to osteoporosis

20 Hours,11 minutes Ago

Washington, May 1 (ANI): A team of scientists at the Garvan Institute for Medical Research have discovered genes in the human genome that are linked to osteoporosis.

This is the first time when an extensive genome-wide search has been conducted to find the genes linked to osteoporosis and fracture.

Researchers identified five regions of interest that appear to warrant further scientific investigation.

There are 30,000 genes in the human genome, but until now few have been unequivocally associated with osteoporosis and fragility fractures.

The Garvan Institute collaborated with the Icelandic genetics company, deCode, for the study that examined 1500 women from Garvan's Dubbo Osteoporosis Epidemiology Study as well as more than 12,000 women from
Iceland and Denmark.

"Genome-wide genotyping, a very demanding and labour-intensive procedure, measures genetic variations called 'Snips' (SNPs or single nucleotide polymorphisms), within each of our 30,000 genes," said Garvan's Associate Professor Tuan Nguyen, who has been involved with the Dubbo project over a period of nearly 20 years.

"The collaborative study examined more than 300,000 such markers and found 12 that were linked to bone mineral density and 6 linked to fragility fractures. Some of these Snips are close to genes that are already known to be associated with osteoporosis," Nguyen added.

Professor John Eisman, Head of Garvan's Bone Program, is very pleased with these findings.

"This international study and the access to the information it brings is a positive example of the value of world-wide scientific collaborations in the area of human genetics. The study identified a number of regions in the human genome that are already known to be important in bone biology, while others are yet to be investigated," he said.

"The next step will be identifying what those genes are and how they might contribute to our understanding of osteoporosis and its prevention. This is an important example of Australian science participating in international science at the highest level," he added. ccording to researchers, the discovery will allow the development of prognostic models, and help clinicians identify individuals with high risk of fracture for intervention.

The study appears online in the New England Journal of Medicine. (ANI)

1 comment:

tokhoa said...

Chân thành chúc mừng Thầy và nhóm nghiên cứu.